| Opponent | Clashes | Record | Win % | Postseason |
|---|---|---|---|---|
| St. Louis Cardinals | 2487 | 1246–1217–24 | .506 | 2–3 |
| Chicago Cubs | 2475 | 1255–1206–14 | .510 | 0–1 |
| Cincinnati Reds | 2361 | 1182–1163–16 | .504 | 8–13 |
| Philadelphia Phillies | 2179 | 1179–992–8 | .543 | — |
| Los Angeles Dodgers | 2064 | 960–1093–11 | .468 | 2–6 |
| Atlanta Braves | 2056 | 1078–966–12 | .527 | 6–8 |
| San Francisco Giants | 2056 | 954–1083–19 | .469 | 3–2 |
| New York Mets | 791 | 406–383–2 | .515 | — |
| Houston Astros | 721 | 372–349 | .516 | — |
| Washington Nationals | 670 | 348–322 | .519 | — |
| San Diego Padres | 526 | 278–248 | .529 | — |
| Milwaukee Brewers | 467 | 203–264 | .435 | — |
| Colorado Rockies | 246 | 129–117 | .524 | — |
| Miami Marlins | 241 | 129–112 | .535 | — |
| Arizona Diamondbacks | 187 | 80–107 | .428 | — |
| Detroit Tigers | 105 | 56–49 | .533 | 4–3 |
| Cleveland Guardians | 60 | 28–32 | .467 | — |
| Minnesota Twins | 58 | 27–31 | .466 | 4–3 |
| Chicago White Sox | 54 | 27–27 | .500 | — |
| Kansas City Royals | 51 | 25–26 | .490 | — |
| Baltimore Orioles | 49 | 23–26 | .469 | 8–6 |
| LS3 | 43 | 26–14–3 | .640 | — |
| New York Yankees | 42 | 15–27 | .357 | 4–7 |
| WSN | 40 | 25–15 | .625 | — |
| CL4 | 39 | 26–13 | .667 | — |
| BLN | 38 | 10–28 | .263 | — |
| Boston Red Sox | 38 | 18–20 | .474 | 3–5 |
| Texas Rangers | 34 | 13–21 | .382 | — |
| Los Angeles Angels | 30 | 15–15 | .500 | — |
| Sacramento Athletics | 30 | 11–19 | .367 | — |
| Tampa Bay Rays | 30 | 13–17 | .433 | — |
| Toronto Blue Jays | 30 | 11–19 | .367 | — |
| Seattle Mariners | 29 | 11–18 | .379 | — |
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